If you're willing to spend a few bucks, I have some recommendations. I am very picky about my hotels, so no Holiday Inns, Microtels, Days Inns, etc for me.
For a real treat, stay at Portofino, one of the most beautiful hotel rooms I've ever seen. The service is wonderful, and it's right there on sight, but far enough away to be quiet and secluded.
The JW Marriott Grande Lakes is indeed grand. The first time we stayed we were upgraded to a junior suite, which was bigger than my friend's apartment. Beautiful bathroom, and some really great views. They have awesome food, make sure to try Primo for a bit of a splurge. The breakfast buffet at Citron is wonderful.
Any Residence Inn, Courtyard, or Springhill Suites is nice as well. Residence Inns and Springhill Suites have an added bonus of free breakfast, with fridges in the rooms. That can be a real money-saver.
If you want a really nice hotel and don't mind staying a bit farther out, one of our favorites when we lived in Lake Worth was the Marriott Orlando Downtown. Very nice rooms, and if you can get a corner room, they're huge. Great service, and if you are a Marriott Elite Rewards member, breakfast is free. You do have to pay for valet parking. The great thing about this place is, because it is a business hotel, weekend rates are sometimes under $100 a night. And you're right downtown.
I recently saw the rooms at the Doubletree Universal while getting conference bids. The rooms are huge, beautiful, with great views of Universal if you face that way. You can walk to the park, or take the free shuttle, and you get warm chocolate chip cookies upon check-in.
The International Plaza (formerly Sheraton World) on Westwood Drive, across from Aquatica and Sea World, recently redid their old, motel-style rooms (outside entrance instead of an interior hallway) and let me tell you, one of the most beautiful rooms I have ever seen, very modern, large, with a microwave and fridge. If you stay there, make sure you specify you want a new room, not a tower room. The tower rooms probably won't be redone for a year or two, and be warned that the lobby and convention areas are undergoing extensive renovations.
The Rosen Plaza is also nice, and the Hilton WDW is great too, and they both have 24 hr "convenience" stores, where you can get booze, a sandwich, a snack, or drinks.