The more I think about it, the more I really want a Fallout house or scare zone. So much potential and different scenarios you could use.
If you want a scare zone, easy and obvious option is to just have it set in any part of the wasteland with raiders everywhere. Or if you want an open house, have it set in the Mojave Wasteland with Deathclaw puppets and an epic finale set in the New Vegas Strip. Plus, imagine this playing as you're going in:
Or (and here's the main house idea in my mind) if you want a more confined and creepy house, have it set in one of the many horrifying Vaults. First one that comes to mind for me is Vault 22, especially since they've nailed the mutant plants theme with Seeds of Extinction. For those who aren't familiar, Vault 22, like all of the vaults in the Fallout universe, was less for protection from the Great War and more for horrific experimentation on its citizens. Vault 22 in this case, had a fungus known as Beauveria mordicana, which when exposed to any organism, infects it and colonizes the body, killing it off and making it a host, turning them into spore carriers, which look terrifying. One of the doctors experimenting with this became infected, which then led to it slowly spreading and infecting the enire vault. In the end, of the 2000 dwellers sent to live in the vault, only 118 made it out, leaving the vault abandoned and left to become an overgrown and continuously-mutating facility.
And I don't think I really need to explain how this could lend itself to be a great house.