Here are a few options for getting from the Sanford Airport to the Royal Pacific hotel in Orlando:
Rental car is convenient if you don't mind driving. Just program the hotel address into your GPS.
Uber/Lyft will likely be the most affordable transportation option, around $30-50 total for 5 people.
Mears Transportation is the official shuttle service for the hotel. You'd need to book online or call in advance. A little more expensive but direct.
Check if the hotel offers a complimentary shuttle. Some do but may have limited schedules.
Traffic can vary but I'd plan about a 30-45 minute drive depending on the time of day. Hope you all have a great visit to Royal Pacific and Orlando!