If you made me choose, I'd want gothic, period-set horror films featuring these characters, in the style of the 2010 WOLF MAN remake.
That said, I thought Whannell's INVISIBLE MAN was great. I'm open to modern-set stories (especially for something like CREATURE FROM THE BLACK LAGOON, which -- once you're out in the jungle, visibly away from the modern world -- would still have an old-fashioned flavor to it). But I do think you run the risk of re-inventing the characters so much that they're functionally no longer really the characters at all.