I'm gonna be real here: I really don't think this film is gonna do well. I really don't see it pulling Endgame or Infinity War numbers with the kind of budget we're talking. Here is why I mention this with a fair amount of confidence:
Infinity War and Endgame did well because it was the culmination of an entire saga they had built up. You had Iron Man, then build up Captain America, the Avengers, then the Guardians and Spidey....but all of them hinted at Thanos being the big bad. Infinity war and Endgame were the culmination of that buildup.
In an alternate reality where Disney actually knew what they were doing, they would realize that they need to create incentive to keep the fans hooked. Now that the Infinity Saga has ended, you need to establish very early who the next "big bad" is going to be. You don't accomplish this by just throwing everything and the kitchen sink at everyone. "Oh here's Wanda Vision! Here's Loki!" Actually you know what, you can argue they did this with Loki by introducing Kang. But when they establish the big bad, they need to be able to show that he is a credible threat.That is where they failed.
Quantamania is a far more pivotal MCU movie than I think people realized. This was supposed to be the one movie that would establish Kang, the next huge villain, as a threat. They could've done this by having him kill of Ant-Man and the other main characters. They could've had an "Oh crap, this dude is serious!" point to establish him as a serious threat....but they fumbled that ball hard. Now with Jonathan Majors out, I really think the best possible move to make at this point is have Doctor Doom be the next main villain and move on from Kang.
While I do think the MCU has made many blunders along the way that has really hurt its chances to maximizing the film's success, I think Deadpool and Wolverine has a decent chance of reinvigorating interest. They can establish the next "big bad" there. They can do things to get excited for the next big MCU movie. But they need to pace themselves from here on out and make sure each film actually builds up to Secret Wars. I can't believe they followed this formula from the Infinity saga and dropped the ball on that hard, but hopefully now they learned. No more "one-and-dones" like The Marvels, She-Hulk, or Shang-Chi. Each movie HAS to build up to Secret Wars or this movie will fail. Deadpool and Wolverine is your only shot at making sure this movie does well, so don't fumble that ball.