Oh I'm sure it will. But it wouldn't be until the next big Avenger film, and even then, I would assume it would be re-released as a marathon with the other Marvel films (like they have been doing in the past). So the full ticket price wouldn't be going to Endgame.
Trust me, I would love to see Avatar dethroned, but it doesn't seem like it will happen anytime soon. However, on the flip side of that, I do have to commend the fact that an original/non IP film was able to become the highest grossing film of all time and still is to this day. That's pretty dang impressive.