I think two E-tickets is a bit much to expect considering Mario's plans consist of only one e-ticket... unless you consider DKC an E-ticket, but that seems much more like a D-ticket range in my eyes.
My ideal with Pokémon is an e-ticket interactive dark ride that's basically Ride and Go Seek from TDL but in the context of Pokemon; go on a lengthy Safari through natural Pokemon environments with 151 A.A. figures of Pokémon. Riders can try to highlight all 151 of them with a camera/flashlight/etc. The other main attraction would be some sort of interactive experience similar to Ollivanders, but with the guests choosing their starter Pokémon. Both of these are accompanied by several family friendly Fantasyland-esque flat rides, such as a Pokémon carousel, a mount Pokémon-themed whip ride, a Charizard themed spinner, etc. And honestly, that's not something I see taking up much room. Pokémon doesn't need a huge area as long as it's fleshed out well.