I remember on the (short-lived) production tram tour at Universal Florida they explained that the alley in the NY backlot area had been used in many movies and was made in a way that it could be dressed for several different time periods. They usually used "Matinee" starring John Goodman as an example of a film that shot in that alley, (although I don't believe there was much else actually shot there besides TV and commercials.) I know some Nickelodeon shows like "Clarissa Explains it All" and "All That" shot a little there. Almost the entire opening for All That was shot there, with additional shots from the garage doors next to what is now the Starbucks, and shots on the porches of the NY apartment buildings across from Fallon/Twister/Ghostbusters.
So yea, the alley in NY is awesome for guests and a nice quiet throughway for me, but was originally built with the intention of showing off how movie sets use curving alley designs to create a sense of going on forever, so they can shoot from many angles without seeing through to the other side.
EDIT: And a scene from "Parenthood" with Steve Martin was shot in that alley as well, dressed to look like the back of Mystery Fun House (remember Mystery Fun House?) And I wouldn't be surprised if a scene from Problem Child 2 was shot there as well. Those were all the movies mentioned on the tram tour. They were so proud of the 3 movies that shot there.